That Burning Feeling is a romantic comedy about the searing pain of looking for love and self in the modern age, and then struggling to make both things coexist happily... It is also about one giant mystery infection with no end and several possible beginnings.

Five college friends take a detour while traveling to their spring break destination. They end up in the remote mountain town of Blueridge, where Karen (Marina Resa) believes her older sister went missing 2 years before. After a few odd encounters with the locals, Karen and her friends decide to continue their journey until an unexpected auto malfunction leaves them stranded. The group takes refuge in a local motel and soon learns that in Blueridge, "missing persons" is just a way of life. One-by-one they begin disappearing until the grizzly discovery is made that the local BBQ Rib Restaurant might be serving up more than anyone had bargained.

Truck-driver Brewster takes over his missing brother's delivery of a load of coffins to a funeral home. He picks up hitchhiking gay couple Cary and Vogel whose relationship is in trouble to help him stay awake but when his GPS leads them into a deserted junkyard, his truck breaks down, stranding them. NIght falls, and the coffins reveal blood-thirty vampires. Now the mismatched trio must barricade themselves in the cab of the truck and try to survive until dawn...